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Gajewski, Thomas F.
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first name Thomas F.
full name Thomas F. Gajewski
label Gajewski, Thomas F.
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Item TypeName
Concept Antigen-Presenting Cells
Concept Calcium-Transporting ATPases
Concept Bone Marrow Cells
Concept Cell Line, Transformed
Concept Antigens, Differentiation, T-Lymphocyte
Concept Cell Differentiation
Concept Cell Movement
Concept Cell Nucleus
Concept Cholera Toxin
Concept Carcinoma, Renal Cell
Concept Biological Therapy
Concept Carcinoma, Basal Cell
Concept Carcinoma, Non-Small-Cell Lung
Concept Cell Membrane
Concept Cell Division
Concept Cell Separation
Concept Clone Cells
Concept Cell-Free System
Concept Cell Cycle
Concept Combined Modality Therapy
Concept Cytological Techniques
Concept Dendritic Cells
Concept Cell Compartmentation
Concept Cytotoxicity Tests, Immunologic
Concept Congresses as Topic
Concept Drug Therapy, Combination
Concept Exudates and Transudates
Concept Killer Cells, Natural
Concept Guanosine Triphosphate
Concept T-Lymphocytes, Helper-Inducer
Concept Immune Tolerance
Concept Fluorescent Antibody Technique
Concept Lymphocyte Culture Test, Mixed
Concept Mice, Transgenic
Concept Neoplasm Transplantation
Concept Neoplastic Cells, Circulating
Concept Hot Temperature
Concept Wilms Tumor
Concept Thymoma
Concept Protein-Tyrosine Kinases
Concept Protein Processing, Post-Translational
Concept Transcription Factors
Concept Receptors, Antigen, B-Cell
Concept RNA Processing, Post-Transcriptional
Concept Time Factors
Concept Tomography, X-Ray Computed
Concept Transcription, Genetic
Concept Interferon Type I
Concept Thrombosis
Concept Thymus Neoplasms
Concept CHO Cells
Concept Biomarkers, Tumor
Concept Tumor Necrosis Factor-alpha
Concept Transplantation Immunology
Concept Ion Transport
Concept Clinical Trials, Phase I as Topic
Concept Testis
Concept Lymphoid Tissue
Concept Transduction, Genetic
Concept Transplantation, Heterologous
Concept Adenocarcinoma, Clear Cell
Concept Hematopoietic Stem Cell Transplantation
Concept Th1 Cells
Concept Trans-Activators
Concept Randomized Controlled Trials as Topic
Concept Cell Culture Techniques
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Tumor Cells, Cultured
Concept Tyrosine
Concept Transforming Growth Factor beta
Concept Cell Adhesion Molecules
Concept PC12 Cells
Concept Salvage Therapy
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept CD4-Positive T-Lymphocytes
Concept Lymphocytes, Tumor-Infiltrating
Concept T-Lymphocyte Subsets
Concept T-Cell Antigen Receptor Specificity
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Treatment Outcome
Concept Guidelines as Topic
Concept Gene Transfer Techniques
Concept Cell Transplantation
Concept CD8-Positive T-Lymphocytes
Concept Cell Proliferation
Concept Transplantation Conditioning
Concept Basic-Leucine Zipper Transcription Factors
Concept Th2 Cells
Concept Transgenes
Concept Tumor Necrosis Factor Receptor Superfamily, Member 9
Concept Hematopoietic Stem Cell Mobilization
Concept Transplantation Tolerance
Concept Jurkat Cells
Concept Protein Tyrosine Phosphatases
Concept Gene Knockout Techniques
Concept Programmed Cell Death 1 Ligand 2 Protein
Concept Positron-Emission Tomography
Concept Tumor Burden
Concept Cell Cycle Proteins
Concept Tumor Escape
Concept Adoptive Transfer
Concept Active Transport, Cell Nucleus
Concept Type C Phospholipases
Concept Tumor Necrosis Factor Ligand Superfamily Member 14
Concept Red-Cell Aplasia, Pure
Concept Taxoids
Concept Molecular Targeted Therapy
Concept SOX9 Transcription Factor
Concept High-Throughput Screening Assays
Concept TOR Serine-Threonine Kinases
Concept High-Throughput Nucleotide Sequencing
Concept Real-Time Polymerase Chain Reaction
Concept Adaptor Proteins, Signal Transducing
Concept T-Lymphocytes, Cytotoxic
Concept Temperature
Concept NFATC Transcription Factors
Concept Toll-Like Receptor 4
Concept Tetradecanoylphorbol Acetate
Concept Lymphoma, B-Cell
Concept Transfection
Concept Tryptophan Oxygenase
Concept Treatment Failure
Concept Transplantation Chimera
Concept Skin Transplantation
Concept Thy-1 Antigens
Concept Organ Transplantation
Concept Cell Polarity
Concept Stromal Cells
Concept Neoadjuvant Therapy
Concept Gene Targeting
Concept Cell Lineage
Concept Cation Transport Proteins
Concept T-Lymphocytes, Regulatory
Concept STAT1 Transcription Factor
Concept STAT5 Transcription Factor
Concept Transcriptome
Concept TNF-Related Apoptosis-Inducing Ligand
Concept Tumor Microenvironment
Concept Programmed Cell Death 1 Receptor
Concept Cell Line, Tumor
Concept STAT6 Transcription Factor
Concept Toll-Like Receptor 9
Concept Receptor, Fibroblast Growth Factor, Type 3
Concept ZAP-70 Protein-Tyrosine Kinase
Concept Forkhead Transcription Factors
Concept Plasma Membrane Calcium-Transporting ATPases
Concept Topoisomerase II Inhibitors
Concept Cell Line
Concept Cell Survival
Concept Cells, Cultured
Concept Clinical Trials as Topic
Concept Immunologic Techniques
Concept Receptors, Antigen, T-Cell
Concept Mast-Cell Sarcoma
Concept T-Lymphocytes
Concept Thoracic Injuries
Concept Thymus Gland
Concept Tracheostomy
Concept Transplantation, Autologous
Concept Transplantation, Homologous
Concept Signal Transduction
Concept Maximum Tolerated Dose
Concept Myeloid Cells
Concept Adaptor Proteins, Vesicular Transport
Concept Quantitative Trait Loci
Academic Article Differential regulation of murine T lymphocyte subsets.
Academic Article Differential function of intestinal intraepithelial lymphocyte subsets.
Academic Article B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro.
Academic Article Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.
Academic Article Liver of MRL/lpr mice contain interleukin-4-producing lymphocytes and accessory cells that support the proliferation of Th2 helper T lymphocyte clones.
Academic Article Induction of a cytolytic T-cell response in mice with a recombinant adenovirus coding for tumor antigen P815A.
Academic Article Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo.
Academic Article Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells.
Academic Article Antigen recognition and allogeneic tumor rejection in CD8+ TCR transgenic/RAG(-/-) mice.
Academic Article Apoptosis meets signal transduction: elimination of a BAD influence.
Academic Article The expression of mouse gene P1A in testis does not prevent safe induction of cytolytic T cells against a P1A-encoded tumor antigen.
Academic Article Blocked Ras activation in anergic CD4+ T cells.
Academic Article Rational development of tumour antigen-specific immunization in melanoma.
Academic Article The immune system as anti-tumor sentinel: molecular requirements for an anti-tumor immune response.
Academic Article Interleukin-12-secreting human papillomavirus type 16-transformed cells provide a potent cancer vaccine that generates E7-directed immunity.
Academic Article B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.
Academic Article Allogeneic peripheral blood stem cell transplantation for metastatic renal cell carcinoma.
Academic Article Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells.
Academic Article Cutting edge: differentiation of antitumor CTL in vivo requires host expression of Stat1.
Academic Article Monitoring specific T-cell responses to melanoma vaccines: ELISPOT, tetramers, and beyond.
Academic Article Biochemical analysis of activated T lymphocytes. Protein phosphorylation and Ras, ERK, and JNK activation.
Academic Article Helper T cell differentiation is controlled by the cell cycle.
Academic Article Polymyositis with respiratory muscle weakness requiring mechanical ventilation in a patient with metastatic thymoma treated with octreotide.
Academic Article B7.1 is a quantitatively stronger costimulus than B7.2 in the activation of naive CD8+ TCR-transgenic T cells.
Academic Article Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
Academic Article CD28 is not required for c-Jun N-terminal kinase activation in T cells.
Academic Article Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12.
Academic Article Allogeneic stem-cell transplantation of renal cell cancer after nonmyeloablative chemotherapy: feasibility, engraftment, and clinical results.
Academic Article Flt-3 ligand and sequential FL/interleukin-2 in patients with metastatic renal carcinoma: clinical and biologic activity.
Academic Article Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).
Academic Article Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12.
Academic Article Cutting edge: spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice.
Academic Article Differential activation of murine TH1 and TH2 clones.
Academic Article Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma.
Academic Article B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.
Academic Article T cell development and function in CrkL-deficient mice.
Academic Article Death of peripheral CD8+ T cells in the absence of MHC class I is Fas-dependent and not blocked by Bcl-xL.
Academic Article Integrating IL-12 into therapeutic cancer vaccines.
Academic Article Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
Academic Article Epitope spreading upon P815 tumor rejection triggered by vaccination with the single class I MHC-restricted peptide P1A.
Academic Article Clinical responses following nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma are associated with expansion of CD8+ IFN-gamma-producing T cells.
Academic Article Temozolomide for melanoma: new toxicities and new opportunities.
Academic Article Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time.
Academic Article Differential Ras signaling via the antigen receptor and IL-2 receptor in primary T lymphocytes.
Academic Article Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Academic Article Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration.
Academic Article Depletion of normal B cells with rituximab as an adjunct to IL-2 therapy for renal cell carcinoma and melanoma.
Academic Article Long-term follow-up of nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma: The University of Chicago Experience.
Academic Article Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy.
Academic Article Gene array and protein expression profiles suggest post-transcriptional regulation during CD8+ T cell differentiation.
Academic Article CD4+ murine T cell clones that express high levels of immunoglobulin binding belong to the interleukin 4-producing T helper cell type 2 subset.
Academic Article Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.
Academic Article Disparate functions of immature and mature human myeloid dendritic cells: implications for dendritic cell-based vaccines.
Academic Article Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double-negative TCR-transgenic T cells.
Academic Article Update on vaccines for solid tumors.
Academic Article Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro.
Academic Article On the TRAIL toward death receptor-based cancer therapeutics.
Academic Article Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.
Academic Article Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells.
Academic Article Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection.
Academic Article Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma.
Academic Article Immune suppression in the tumor microenvironment.
Academic Article Tumor progression despite massive influx of activated CD8(+) T cells in a patient with malignant melanoma ascites.
Academic Article Molecular regulation of T-cell anergy.
Academic Article The p815 mastocytoma tumor model.
Academic Article Production of TH1 and TH2 cell lines and clones.
Academic Article Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma.
Academic Article Diagnosis and treatment of mycoplasma-contaminated cell cultures.
Academic Article Diagnosis and treatment of Mycoplasma-contaminated cell cultures.
Academic Article Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma.
Academic Article Phase I/II trial of tremelimumab in patients with metastatic melanoma.
Academic Article Melanoma presenting as circulating tumor cells associated with failed angiogenesis.
Academic Article Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment.
Academic Article Diagnosis and treatment of mycoplasma-contaminated cell cultures.
Academic Article The HLA-A2-restricted PSMA peptide LLHETDSAV is poorly immunogenic in patients with metastatic prostate cancer.
Academic Article Metabolic mechanisms of tumor resistance to T cell effector function.
Academic Article Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment.
Academic Article Negative regulation of T-cell function by PD-1.
Academic Article Peripheral survival of naïve CD8+ T cells.
Academic Article Protein kinase Ctheta focusing at the cSMAC is a consequence rather than cause of TCR signaling and is dependent on the MEK/ERK pathway.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. IV. Murine CTL clones produce IL-3 and GM-CSF, the activity of which is masked by the inhibitory action of secreted IFN-gamma.
Academic Article A randomized phase II trial of interleukin-2 in combination with four different doses of bryostatin-1 in patients with renal cell carcinoma.
Academic Article Identifying and overcoming immune resistance mechanisms in the melanoma tumor microenvironment.
Academic Article Induction of cytotoxic granules in human memory CD8+ T cell subsets requires cell cycle progression.
Academic Article Immune resistance orchestrated by the tumor microenvironment.
Academic Article T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.
Academic Article A phase II study of oxaliplatin, docetaxel, and GM-CSF in patients with previously treated advanced melanoma.
Academic Article Cross-priming of T cells to intracranial tumor antigens elicits an immune response that fails in the effector phase but can be augmented with local immunotherapy.
Academic Article Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.
Academic Article Homeostatic proliferation of naïve CD8+ T cells depends on CD62L/L-selectin-mediated homing to peripheral LN.
Academic Article Improved melanoma survival at last! Ipilimumab and a paradigm shift for immunotherapy.
Academic Article Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells.
Academic Article Emerging strategies in regulatory T-cell immunotherapies.
Academic Article Costimulatory and coinhibitory receptors in anti-tumor immunity.
Academic Article Molecular profiling of melanoma and the evolution of patient-specific therapy.
Academic Article Use of Cre-adenovirus and CAR transgenic mice for efficient deletion of genes in post-thymic T cells.
Academic Article Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.
Academic Article The immune score as a new possible approach for the classification of cancer.
Academic Article Innate immune sensing of cancer: clues from an identified role for type I IFNs.
Academic Article A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.
Academic Article Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011".
Academic Article Workshop on immunotherapy combinations. Society for Immunotherapy of Cancer annual meeting Bethesda, November 3, 2011.
Academic Article Nakahara memorial lecture. Regulation of T lymphocyte responses: interactions among receptors.
Academic Article ICAM-1 contributes to but is not essential for tumor antigen cross-priming and CD8+ T cell-mediated tumor rejection in vivo.
Academic Article Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells.
Academic Article Evidence implicating I region-restricted antigen presentation in alloantigen and nominal antigen recognition by a dual-reactive helper T lymphocyte clone.
Academic Article Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones.
Academic Article Regulation of T-cell activation: differences among T-cell subsets.
Academic Article An adenoviral vector for probing promoter activity in primary immune cells.
Academic Article Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo.
Academic Article Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.
Academic Article Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer.
Academic Article Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle/pericytes.
Academic Article Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
Academic Article Defining the critical hurdles in cancer immunotherapy.
Academic Article Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A.
Academic Article Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.
Academic Article Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.
Academic Article Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases.
Academic Article From defined human tumor antigens to effective immunization?
Academic Article The expanding universe of regulatory T cell subsets in cancer.
Academic Article An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.
Academic Article "Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.
Academic Article CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.
Academic Article Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-?1 phosphorylation.
Academic Article SITC/iSBTc Cancer Immunotherapy Biomarkers Resource Document: online resources and useful tools - a compass in the land of biomarker discovery.
Academic Article Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. II. IFN-gamma inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor.
Academic Article Interleukin 2 and concanavalin A stimulate interferon-gamma production in a murine cytolytic T cell clone by different pathways.
Academic Article Control of T lymphocyte signal transduction through clonal anergy.
Academic Article A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3.
Academic Article Expression and function of CTLA-4 in Th1 and Th2 cells.
Academic Article Regulation of anti-immunoglobulin-induced B lymphoma growth arrest by transforming growth factor beta 1 and dexamethasone.
Academic Article Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.
Academic Article A phase II study of bryostatin-1 and paclitaxel in patients with advanced non-small cell lung cancer.
Academic Article PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells.
Academic Article Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells.
Academic Article Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies.
Academic Article Overcoming immune resistance in the tumor microenvironment by blockade of indoleamine 2,3-dioxygenase and programmed death ligand 1.
Academic Article Lymphoma-infiltrating immune cells.
Academic Article CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium.
Academic Article Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.
Academic Article Report on the ISBTC mini-symposium on biologic effects of targeted therapeutics.
Academic Article Immune-mediated red cell aplasia after anti-CTLA-4 immunotherapy for metastatic melanoma.
Academic Article PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model.
Academic Article Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.
Academic Article Beta-catenin does not regulate memory T cell phenotype.
Academic Article Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas.
Academic Article Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment.
Academic Article Review of the 25th annual scientific meeting of the International Society for Biological Therapy of Cancer.
Academic Article Phase I studies of sirolimus alone or in combination with pharmacokinetic modulators in advanced cancer patients.
Academic Article [Use of valvular drainage of the pleural cavity in the treatment of spontaneous pneumothorax].
Academic Article [Parotitis as a postoperative complication].
Academic Article [A case of effusion of chyle into the pleural and peritoneal cavity].
Academic Article [Surgical treatment of a case of giant hypertrophy of the mandible].
Academic Article [Perthes' syndrome after crushing of the thorax].
Academic Article [Indications concerning the management of patients with artificial anus].
Academic Article CD40 ligation reverses T cell tolerance in acute myeloid leukemia.
Academic Article Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012".
Academic Article Cancer classification using the Immunoscore: a worldwide task force.
Academic Article Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma.
Academic Article Type I interferon response and innate immune sensing of cancer.
Academic Article Cancer immunotherapy.
Academic Article Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).
Academic Article Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy.
Academic Article Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment.
Academic Article Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.
Academic Article Targeting the tumor microenvironment with interferon-ß bridges innate and adaptive immune responses.
Academic Article Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933.
Academic Article Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: a phase 1b study.
Academic Article Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013.
Academic Article Therapeutic activity of high-dose intratumoral IFN-ß requires direct effect on the tumor vasculature.
Academic Article Metabolic response by FDG-PET to imatinib correlates with exon 11 KIT mutation and predicts outcome in patients with mucosal melanoma.
Academic Article Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction.
Academic Article STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
Academic Article New perspectives on type I IFNs in cancer.
Academic Article The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma.
Academic Article Primary murine CD4+ T cells fail to acquire the ability to produce effector cytokines when active Ras is present during Th1/Th2 differentiation.
Academic Article STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article Innate immune recognition of cancer.
Academic Article Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Academic Article T cell-NF-?B activation is required for tumor control in vivo.
Academic Article Innate and adaptive immune cells in the tumor microenvironment.
Academic Article Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment.
Academic Article Rational combinations of immunotherapeutics that target discrete pathways.
Academic Article Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial.
Academic Article Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition.
Academic Article Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.
Academic Article The STING pathway and the T cell-inflamed tumor microenvironment.
Academic Article Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.
Academic Article Melanoma-intrinsic ß-catenin signalling prevents anti-tumour immunity.
Academic Article The Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment.
Academic Article A new paradigm for tumor immune escape: ß-catenin-driven immune exclusion.
Academic Article Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy.
Academic Article Future perspectives in melanoma research: meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014.
Academic Article Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.
Academic Article A phase II study of cediranib, an oral VEGF inhibitor, in previously untreated patients with metastatic or recurrent malignant melanoma.
Academic Article Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection.
Academic Article Tumor and Host Factors Controlling Antitumor Immunity and Efficacy of Cancer Immunotherapy.
Academic Article Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.
Academic Article MYC - a thorn in the side of cancer immunity.
Academic Article Single dose denileukin diftitox does not enhance vaccine-induced T cell responses or effectively deplete Tregs in advanced melanoma: immune monitoring and clinical results of a randomized phase II trial.
Academic Article Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article The host STING pathway at the interface of cancer and immunity.
Academic Article Manipulating the microbiome to improve the efficacy of immunotherapy.
Academic Article NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells.
Academic Article Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy.
Academic Article Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy.
Academic Article Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
Academic Article Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015.
Academic Article Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma.
Academic Article Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma.
Academic Article Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.
Academic Article Innate immune signaling and regulation in cancer immunotherapy.
Academic Article The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.
Academic Article Tumor-intrinsic oncogene pathways mediating immune avoidance.
Academic Article Phase 2 trial of talabostat in stage IV melanoma.
Academic Article Reciprocal expression of indoleamine-2,3-dioxygenase (IDO) and arginase-I in metastatic melanoma tumors.
Academic Article Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting.
Academic Article Efficacy and safety of ipilimumab induction and maintenance dosing in patients with advanced melanoma who progressed on one or more prior therapies.
Academic Article Safety and efficacy of the antiganglioside GD3 antibody ecromeximab (KW2871) combined with high-dose interferon-a2b in patients with metastatic melanoma.
Academic Article Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Academic Article The Microbiota: A New Variable Impacting Cancer Treatment Outcomes.
Academic Article Impact of oncogenic pathways on evasion of antitumour immune responses.
Academic Article Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November-2 December, 2017, Naples, Italy).
Academic Article The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
Academic Article The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies.
Academic Article Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab.
Academic Article WT1 peptide vaccine in Montanide in contrast to poly ICLC, is able to induce WT1-specific immune response with TCR clonal enrichment in myeloid leukemia.
Academic Article Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity.
Academic Article Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy.
Academic Article An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0.
Academic Article Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037).
Academic Article Back from the dead: TIL apoptosis in cancer immune evasion.
Academic Article Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
Academic Article Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity.
Academic Article A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors.
Academic Article Fast Forward - Neoadjuvant Cancer Immunotherapy.
Academic Article Severe hemophagocytic lymphohistiocytosis in a melanoma patient treated with ipilimumab + nivolumab.
Academic Article Pseudoprogression manifesting as recurrent ascites with anti-PD-1 immunotherapy in urothelial bladder cancer.
Academic Article Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy.
Academic Article Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment.
Academic Article High-Throughput Stability Screening of Neoantigen/HLA Complexes Improves Immunogenicity Predictions.
Academic Article WNT/ß-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers.
Academic Article Major pathologic response on biopsy (MPRbx) in patients with advanced melanoma treated with anti-PD-1: evidence for an early, on-therapy biomarker of response.
Academic Article Brain Tumor Microenvironment and Host State: Implications for Immunotherapy.
Academic Article Phase 1/2 study of epacadostat in combination with ipilimumab in patients with unresectable or metastatic melanoma.
Academic Article Perspectives in melanoma: meeting report from the Melanoma Bridge (November 29th-1 December 1st, 2018, Naples, Italy).
Academic Article STING pathway agonism as a cancer therapeutic.
Academic Article Secondary resistance to immunotherapy associated with ß-catenin pathway activation or PTEN loss in metastatic melanoma.
Academic Article Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF-Mutant Melanoma.
Academic Article ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients.
Academic Article Major pathologic response on biopsy (MPRbx) in patients with advanced melanoma treated with anti-PD-1: evidence for an early, on-therapy biomarker of response.
Academic Article Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-?-signaling mutant cancer cells.
Academic Article A case of dual-mechanism immune-related anaemia in a patient with metastatic melanoma treated with nivolumab and ipilimumab.
Academic Article Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19.
Academic Article Strategies to overcome resistance to PD-1 inhibitors.
Academic Article cDC1 dysregulation in cancer: An opportunity for intervention.
Academic Article COVIDOSE: Low-dose tocilizumab in the treatment of Covid-19.
Academic Article Perspectives in melanoma: meeting report from the "Melanoma Bridge" (December 5th-7th, 2019, Naples, Italy).
Academic Article Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.
Academic Article Improved Survival Associated with Local Tumor Response Following Multisite Radiotherapy and Pembrolizumab: Secondary Analysis of a Phase I Trial.
Academic Article COVIDOSE: A Phase II Clinical Trial of Low-Dose Tocilizumab in the Treatment of Noncritical COVID-19 Pneumonia.
Academic Article Novel response to neoadjuvant anti-PD1 therapy for a patient with retrocaval melanotic schwannoma.
Academic Article Cost-Effectiveness Analysis of Adjuvant Therapy for BRAF-Mutant Resected Stage III Melanoma in Medicare Patients.
Academic Article Sensitive detection and quantification of SARS-CoV-2 in saliva.
Academic Article Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 3rd-5th, 2020, Italy).
Academic Article Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma.
Academic Article ASO Visual Abstract: Cost-Effectiveness Analysis of Adjuvant Therapy for BRAF-Mutant Resected Stage 3 Melanoma in Medicare Patients.
Academic Article Immune cell and tumor cell-derived CXCL10 is indicative of immunotherapy response in metastatic melanoma.
Academic Article Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction.
Academic Article PAK4 as a cancer immune-evasion target.
Academic Article Dietary modulation of the gut microbiome as an immunoregulatory intervention.
Academic Article Wilms tumor reveals DNA repair gene hyperexpression is linked to lack of tumor immune infiltration.
Academic Article Antibody and T cell responses to COVID-19 vaccination in patients receiving anticancer therapies.
Academic Article Microbiome-based interventions: therapeutic strategies in cancer immunotherapy.
Academic Article Insights from a Rapidly Implemented COVID-19 Biobank Using Electronic Consent and Informatics Tools.
Academic Article CXCL9 and CXCL10 bring the heat to tumors.
Academic Article Checkpoint Blockade-Induced Dermatitis and Colitis Are Dominated by Tissue-Resident Memory T Cells and Th1/Tc1 Cytokines.
Academic Article Randomized, Double-Blind, Placebo-Controlled, Global Phase III Trial of Talimogene Laherparepvec Combined With Pembrolizumab for Advanced Melanoma.
Academic Article Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 2nd - 4th, 2021, Italy).
Academic Article Proceedings From the ASCO/College of American Pathologists Immune Checkpoint Inhibitor Predictive Biomarker Summit.
Academic Article Lymphatic coagulation and neutrophil extracellular traps in lung-draining lymph nodes of COVID-19 decedents.
Academic Article Highly aneuploid non-small cell lung cancer shows enhanced responsiveness to concurrent radiation and immune checkpoint blockade.
Academic Article Association Between Rheumatic Autoantibodies and Immune-Related Adverse Events.
Concept Fecal Microbiota Transplantation
Concept Positron Emission Tomography Computed Tomography
Concept Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Concept B-Cell CLL-Lymphoma 10 Protein
Concept Protein Kinase C-theta
Concept MCF-7 Cells
Concept Extracellular Traps
Concept In Vitro Techniques
Concept Response Evaluation Criteria in Solid Tumors
Academic Article Tissue-resident memory T cells in immune-related adverse events: friend or foe?
Academic Article Germline immunomodulatory expression quantitative trait loci (ieQTLs) associated with immune-related toxicity from checkpoint inhibition.
Academic Article Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas.
Academic Article Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 1st-3rd, 2022-Naples, Italy).
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